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  • Title: Anti-T cell antibody in juvenile rheumatoid arthritis.
    Author: Borel Y, Morimoto C, Cairns L, Mantzouranis E, Strelkauskas AJ, Schlossman SF.
    Journal: J Rheumatol; 1984 Feb; 11(1):56-61. PubMed ID: 6366227.
    Abstract:
    One hundred-and-seven patients with juvenile rheumatoid arthritis (JRA) were studied for the presence or absence of an autoantibody in their sera directed against T cells. Using an indirect immunofluorescence technique on a fluorescence activated cell sorter, 71% of all patients were found to be positive on at least one sample. When studied according to the mode of onset of disease 75% of those with systemic onset, 70% with a pauciarticular, and 68% of those with a polyarticular onset were positive. Longitudinal studies appeared to suggest a correlation with disease activity, particularly in individual patients who were positive, while remission was almost invariably associated with negative testing for anti-T cell antibodies. These findings suggest that the anti-T cell antibody may be a useful diagnostic test in JRA and of benefit in monitoring disease activity and remission of disease.
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