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  • Title: Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial.
    Author: Gray GR, Smith IS, McKenzie I, Crean GP, Gillespie G.
    Journal: Lancet; 1977 Jan 01; 1(8001):4-7. PubMed ID: 63673.
    Abstract:
    40 adult outpatients with active endoscopically proven duodenal ulceration, who would otherwise have merited elective ulcer surgery, entered a double-blind trial of either cimetidine (1g/day) or placebo. After twenty-eight days, 17 of 20 (85%) patients receiving cimetidine showed ulcer healing, compared with 5 of 20 patients receiving placebo (p less than 0.0005). Patients receiving cimetidine had significantly more pain-free days and pain-free nights than those receiving placebo. There was good correlation between ulcer healing and symptomatic relief (p less than 0.0005).
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