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  • Title: [Comparative study of the immunogenicity of neurotoxin preparations and their separate fractions obtained from Shigella sonnei, phases I and II].
    Author: Kamzolkina NB, Iarovaia LM.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1984 Jan; (1):23-6. PubMed ID: 6367318.
    Abstract:
    The immunogenicity of the preparations of phase I S. sonnei neurotoxin, determined by the keratoconjunctival test on guinea pigs, is linked mainly with the presence of a high-molecular component other than endotoxin in these preparations. The preparations of phase II S. sonnei neurotoxin do not contain the endotoxin and high-molecular antigens of S. sonnei, phase I, which protect guinea pigs from the development of experimental keratoconjunctivitis; these preparations are toxic for mice and possess low immunogenicity.
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