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  • Title: Spontaneous release of leukocyte migration inhibition factor (LMIF) by lymphocytes in chronic lymphatic leukemia patients.
    Author: Crivii SM, Crişan M, Crişan M.
    Journal: Arch Geschwulstforsch; 1984; 54(1):85-9. PubMed ID: 6367694.
    Abstract:
    Leukocyte migration inhibition factor (LMIF) activity expressed as a migration index was studied in sera of 13 chronic lymphatic leukemia (CLL) patients and 14 healthy subjects. LMIF activity was present in 92.8% of CLL patients and 14% of controls. The LMIF activity of lymphocyte culture supernatants in the same patients and 7 controls was also studied. A LMIF-like activity was found both, in the sera and phytohemagglutinin (PHA) unstimulated cell supernatants in 9 of 13 patients (69.2%). These results demonstrate the ability of malignant B cells to release LMIF or LMIF-like factors spontaneously.
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