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  • Title: Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate.
    Author: Malandrino S, Campagnoli G, Borsa M, Guidoboni R, Tonon GC.
    Journal: Arzneimittelforschung; 1984; 34(1):30-1. PubMed ID: 6367754.
    Abstract:
    Tri-potassium di-citrato bismuthate given intragastrically to rats 60 min before administration of necrotizing agents such as 85% ethanol, 0.2 N sodium hydroxide or acidified indomethacin, reduced the formation of mucosal lesions dose-dependently. Prostaglandin I2 (PGI2)-like material, determined by bioassay, was higher in the gastric mucosa of animals treated with bismuth subcitrate complex than in control animals.
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