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  • Title: Osteogenic sarcoma producing human chorionic gonadotrophin. Case report with immunohistochemical studies.
    Author: Kalra JK, Mir R, Kahn LB, Wessely Z, Shah AB.
    Journal: Cancer; 1984 May 15; 53(10):2125-8. PubMed ID: 6367934.
    Abstract:
    An osteogenic sarcoma occurring in a 22-year-old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B-hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B-hCG while immunohistochemical staining of the tumor cells was strongly positive for B-hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma.
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