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  • Title: Ultimobranchial gland of the domestic fowl. Two types of secretory cells involved in calcitonin metabolism.
    Author: Treilhou-Lahille F, Lasmoles F, Taboulet J, Barlet JP, Milhaud G, Moukhtar MS.
    Journal: Cell Tissue Res; 1984; 235(2):439-48. PubMed ID: 6368001.
    Abstract:
    The ultimobranchial gland (UBG) of birds is particularly rich in calcitonin, the hypocalcaemic hypophosphataemic hormone, that is secreted by the C-cells of the mammalian thyroid. The principal cells of the UBG have a striking resemblance with the mammalian C-cells, i.e., they possess small intracytoplasmic dense-core secretory granules, 150-300 nm in diameter. The gland also contains a second, morphologically distinct, endocrine cell type with larger granules, 500-800 nm in diameter. A sensitive immunocytochemical reaction was developed with the use of antibodies against salmon calcitonin. By means of this technique the presence of calcitonin-immunoreactive molecules was demonstrated in both secretory cell types of the UB gland of the chicken. This gland can thus be considered as a homogeneous calcitonin-producing tissue. Whether the secretory products are identical is discussed and differences in the secretory pathways are suggested.
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