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  • Title: Prostacyclin bioassays using inhibition of platelet aggregation and relaxation of rabbit coeliac artery.
    Author: Fournau P, Bonnet P, Bourgue MF, Paris J.
    Journal: J Pharmacol Methods; 1984 Mar; 11(1):53-60. PubMed ID: 6371386.
    Abstract:
    Bioassays of prostacyclin by inhibition of velocity and maximum of both irreversible and biphasic platelet aggregation, and by relaxation of the potassium-contracted isolated superfused rabbit coeliac artery have been undertaken. The use of each parameter is possible within a range of PGI2 concentrations, which have been determined for each of the five parameters studied. The optimal concentrations of PGI2 for a bioassay have also been determined, corresponding to each range.
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