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  • Title: [Results with the IgM-FTA-Abs and IgM-TPHA tests in the study of seropositive syphilitic sera].
    Author: Brade V, Beuscher HU.
    Journal: Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol; 1983 Jul; 254(4):521-7. PubMed ID: 6372330.
    Abstract:
    The IgM fraction was separated by gel filtration chromatography from patient sera which were positive in the FTA-abs-test as well as in the TPHA-test. After absorption the isolated IgM fraction was tested for specific IgM antibodies against Treponema pallidum in the IgM-FTA-abs- and also in the IgM-TPHA-test. The following results were obtained: Both IgM tests often showed positive reactions even with negative results in the cardiolipin complement fixation assay (CFA) (Tables 1 and 2). In most positive cases specific IgM was detectable with both IgM tests in the same sample (Table 3). The CFA titers were low (less than 1:20) in the majority of cases which did not have detectable IgM (Tables 1 and 3). The CFA titers were prevailingly high (greater than 1:20) where the IgM tests gave positive results (Table 1 and 3). Clinical symptoms of active syphilis were only reported for cases with high CFA titer and positive IgM tests in the same sample. Therefore only these latter results of diagnostic tests can be clearly interpreted to indicate a requirement for specific therapy against syphilis.
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