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  • Title: Recurrent focal glomerulosclerosis in renal transplants.
    Author: Axelsen RA, Seymour AE, Mathew TH, Fisher G, Canny A, Pascoe V.
    Journal: Clin Nephrol; 1984 Feb; 21(2):110-2, 113-4. PubMed ID: 6373077.
    Abstract:
    Among 431 renal transplants in 380 patients, 4 patients were identified with focal glomerulosclerosis characterized by presentation with corticosteroid-resistant nephrotic syndrome, early development of histological lesions, mesangial proliferation and rapid progression into chronic renal failure. After transplantation, all patients had early proteinuria and the 4 grafts surviving beyond 3 months developed recurrent glomerular lesions with severe nephrotic syndrome and progression to graft failure. In one patient, recurrent disease developed in two successive grafts. Focal glomerulosclerosis is a nonspecific glomerular lesion, but identification of specific clinical and pathological features may provide guidelines that will predict the risk of its recurrence in transplanted kidneys.
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