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  • Title: Pancreatic alpha cell autoantibodies and glucagon response to arginine.
    Author: Winter WE, Maclaren NK, Riley WJ, Unger RH, Neufeld M, Ozand PT.
    Journal: Diabetes; 1984 May; 33(5):435-7. PubMed ID: 6373451.
    Abstract:
    The frequency and significance of cytoplasmic pancreatic alpha cell autoantibodies (ACA) were investigated in 2102 healthy controls, 879 patients with insulin-dependent diabetes mellitus (IDDM) who were negative for islet cell autoantibodies (ICA), and 1567 relatives of IDDM patients. ACA were found in approximately 1 in 200 people of all ages and were not significantly associated with IDDM, the IDDM-associated HLA phenotypes DR3 and DR4, or thyrogastric or adrenal autoantibodies. Of 11 ACA-positive patients studied by arginine stimulation tests, none had frank glucagon deficiency. Thus, ACA do not appear to be associated with defective alpha cell function or with IDDM.
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