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  • Title: [Indefinite survival of pancreatic allografts under cyclosporin A treatment in rats].
    Author: Domergue J, Bouhaddioui N, Barneon G, Marchal G.
    Journal: J Chir (Paris); 1984 Mar; 121(3):195-201. PubMed ID: 6373804.
    Abstract:
    Reports in the published literature suggest that cyclosporine A is less effective in the prevention of pancreatic graft rejection. Prolonged survival (97.9 days) of pancreatic allografts was obtained by the use of cyclosporine A in the rat, and indefinite survival was reported in 2 animals. Toxic accidents related to the compound were not observed. A complete histologic and metabolic study of pancreatic grafts showed that two types of response were possible according to whether the graft was rejected or tolerated. Cyclosporine A should be considered as a basic immunosuppressive agent for all types of allograft, including the pancreatic type.
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