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  • Title: [Pharmacokinetic studies on ceftazidime in the obstetrical and gynecological field].
    Author: Ito K, Kondo H, Hayasaki M, Noda K.
    Journal: Jpn J Antibiot; 1984 Jan; 37(1):18-22. PubMed ID: 6374194.
    Abstract:
    Concentrations of ceftazidime ( CAZ ) were examined in the pelvic dead space exudate in 6 patients who received radical hysterectomy due to uterocervical cancer. Data analysis was performed by the simulation curves prepared from pharmacokinetics parameters using the three-compartment model. Following 1-hour intravenous drip infusion of 1 g of CAZ , the mean drug concentration in venous blood was 75.54 micrograms/ml at 1 hour after start of the infusion. The mean CAZ level in the pelvic dead space exudate was as high as 23.87 micrograms/ml at 2.09 hours after start of the infusion, and the AUC was 149.11 micrograms . hr/ml. The above results suggest that CAZ is a useful drug clinically with good penetration into the pelvic dead space.
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