These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Demonstration of circulating CEA or CEA-like antigens and immunoglobulin G containing immune complexes in colorectal carcinoma].
    Author: Pompecki R.
    Journal: Klin Wochenschr; 1984 Apr 02; 62(7):307-14. PubMed ID: 6374276.
    Abstract:
    A sandwich method was developed for the detection of carcinoembryonic antigen (CEA) and CEA-like molecules and immunoglobulin G (IgG) containing immune complexes (CEA-IgG-IC) in human sera. Rabbit anti-CEA ( Dako , FRG) was adsorbed to polypropylene tubes. CEA-like molecules and IgG containing immune complexes bound to the solid phase. They were detected by binding peroxidase-labelled anti-IgG antibodies and quantified by measuring the optical density (OD) at 492 nm after oxidation of orthophenylene diamine. Sera of 68 controls had a mean OD 492 of 1.19 +/- 0.26 (means +/- SD). An extinction of more than 1.97 (means + 3 SD) was judged as elevated. Fourteen of 69 patients after surgical treatment of colorectal carcinoma showed elevated OD 492 up to a value of 3.92. In five patients with benign diseases of colon or rectum normal values were found. In 7 of 41 patients without recurrence or metastases CEA-IgG-IC were elevated although the CEA was normal, and in one case both parameters were elevated. In four of 22 patients with tumor progression CEA-IgG-IC and CEA were elevated, whereas in two cases only CEA-IgG-IC were found.
    [Abstract] [Full Text] [Related] [New Search]