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  • Title: [Pathological anatomy and pathogenesis of experimental pancreatitis].
    Author: Kanaian AS, Permiakov NK, Titova GP, Arabadzhian KP.
    Journal: Arkh Patol; 1984; 46(4):64-71. PubMed ID: 6375640.
    Abstract:
    The necrotic and inflammatory processes in the albino rats pancreas were studied by histological, immunomorphological and electron microscopic techniques after freezing of the pancreas. Early morphological sings of acinar cells destruction were revealed. The mechanism of secret "leakage" from zimogen granules into acinar cell cytoplasm was shown. The stages of pathologic process corresponding to different types of pancreatitis were established. The inflammatory reaction formed in the stage of parenchymal necrosis was characterised by an early activation of fibroblastic and macrophagal cells and by the delay of necrotic tissue elimination with their following calcification. The chronic pancreatitis developed on the immune basis in the intact parts of the pancreas.
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