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  • Title: Immunologic characterization of Reed-Sternberg cells and other cell components in lymph nodes with Hodgkin's disease.
    Author: Watanabe S, Shimosato Y, Sato Y, Shimoyama M, Tobinai K, Mikata A.
    Journal: Acta Pathol Jpn; 1984 Mar; 34(2):241-50. PubMed ID: 6377817.
    Abstract:
    Seven lymph nodes from patients with Hodgkin's disease were immunologically studied. Histologically these cases consisted of 3 lymphocyte predominance, 2 mixed cellularity, and 2 nodular sclerosis. Positive staining of mononuclear Hodgkin- and multinuclear Reed-Sternberg (RS) cells were obtained with anti-Ia like antigens and OKT9 (anti-transferrin receptor) monoclonal antibodies. No supportive data for discussing similarity of RS cells with ordinary histiocytes, B-lymphocytes or T-lymphocytes were obtained from the study of surface phenotype, although some analogy was present with histiocytes. Small lymphocytes around RS cells were helper/inducer T-lymphocytes, and the relationship between these T lymphocytes and RS cells was discussed.
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