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  • Title: A colicin A fragment containing the receptor binding domain can be directed to the periplasmic space in E. coli through gene fusion.
    Author: Crozel V, Lazdunski C, Lloubes R, Cavard D.
    Journal: FEBS Lett; 1984 Jul 09; 172(2):183-8. PubMed ID: 6378656.
    Abstract:
    The central region of the colicin A polypeptide chain has been fused to the N-terminal part of beta-lactamase through genetic recombination. This region comprising amino acid residues 70-335 confers on the hybrid protein the ability to protect sensitive cells from the lethal action of colicin A. Although colicin A belongs to the cytoplasmic compartment of E. coli, export of the hybrid protein to the periplasmic space was promoted by the signal peptide of beta-lactamase.
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