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  • Title: Immunoregulation of T-dependent responses by a cloned dendritic cell.
    Author: Clayberger C, DeKruyff RH, Fay R, Pavlakis M, Cantor H.
    Journal: J Immunol; 1984 Sep; 133(3):1174-8. PubMed ID: 6379045.
    Abstract:
    We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses. Clone Den-1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co-recognize nominal antigen plus I-Ab gene products. In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells. The relationship of this clone to heterogeneous populations of dendritic cells and other accessory cells is discussed.
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