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  • Title: A comparison of indoprofen and indomethacin in the treatment of ankylosing spondylitis.
    Author: Armstrong RD, Laurent R, Panayi GS.
    Journal: Pharmatherapeutica; 1984; 3(10):637-41. PubMed ID: 6379678.
    Abstract:
    A double-blind, crossover trial was carried out to compare the effectiveness and tolerance of indoprofen with indomethacin in the treatment of ankylosing spondylitis. Nineteen patients entered the study and 1 was withdrawn for reasons unrelated to therapy. Patients received 4-weeks' treatment in random order, with 200 mg indoprofen 4-times daily and 25 mg indomethacin 4-times daily. Most subjective and objective clinical measurements of disease activity showed a comparable degree of improvement with either drug although few statistically significant changes were observed. There was no statistically significant difference between treatments and, although gastro-intestinal side-effects occurred more commonly with indoprofen, patients known to be intolerant of indomethacin had been excluded from this trial.
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