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  • Title: 2-DG-induced glucopenia does elicit feeding in rats with lesions of the zona incerta.
    Author: Tepper BJ, Kanarek RB.
    Journal: Physiol Behav; 1984 Mar; 32(3):441-6. PubMed ID: 6379706.
    Abstract:
    Rats with lesions of the rostral zona incerta (ZI) were maintained on either a palatable liquid diet or Purina Laboratory Chow and tested for their ability to respond to acute cellular glucoprivation. Food intake was measured at two-hour intervals during a six-hour feeding test following the administration of either 2-deoxy-D-glucose (2-DG) (200, 400 and 600 mg/kg) or insulin (4 U/rat). ZI-lesioned rats maintained on the liquid diet responded vigorously both to 2-DG and insulin-induced glucopenia. In contrast, ZI-lesioned animals consuming chow failed to augment feeding following 2-DG administration, although they did increase food intake as a function of insulin administration. These data suggest that dietary factors play an important role in the feeding responses of ZI-lesioned animals and must be considered when drawing conclusions about feeding behavior in brain-damaged animals.
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