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  • Title: A double-blind, interpatient comparison of plain and slow-release ketoprofen in osteoarthritis.
    Author: Marcolongo R, Rubegni M, Provvedi D, Giordano N, Frati E, Bruni G.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1984 Jul; 22(7):377-81. PubMed ID: 6381334.
    Abstract:
    Eighty patients with osteoarthritis of various localization completed a double-blind, parallel-group trial of 2 weeks' duration comparing the efficacy and tolerance of ketoprofen slow-release capsules (150 mg) given either as a morning or a midday or an evening dose with that of ketoprofen conventional capsules (50 mg) 3X daily. All regimens were associated with a statistically significant improvement in pain at rest, pain on active motion, quality of sleep, and spine flexion, but there was no difference between treatments. The tolerance of ketoprofen was also similar in all groups. In view of the alleged better compliance of patients with once-daily medications, the new slow-release formulation of ketoprofen appears to be a useful alternative to the conventional capsules.
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