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  • Title: Pharmacological evidence for the involvement of Na+ channels in the release of catecholamines from perfused adrenal glands.
    Author: Ito S, Nakazato Y, Ohga A.
    Journal: Br J Pharmacol; 1978 Mar; 62(3):359-61. PubMed ID: 638314.
    Abstract:
    Veratridine (0.1 mM) was found to be effective in producing an increase in the catecholamine output from perfused guinea-pig adrenal glands in the presence of high concentrations of hexamethonium (1.83 mM) and atropine (28.8 micrometer). The response to veratridine was abolished by removal of either Na+ or Ca2+ from perfusion media and by the addition of tetrodotoxin (0.1 micrometer). It is suggested that the response to veratridine may be due to an increase in the tetrodotoxin-sensitive Na+ permeability of chromaffin cell membranes.
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