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  • Title: Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
    Author: Dolan ME, Scicchitano D, Singer B, Pegg AE.
    Journal: Biochem Biophys Res Commun; 1984 Aug 30; 123(1):324-30. PubMed ID: 6383380.
    Abstract:
    Partially purified preparations of O6-alkylguanine-DNA alkyltransferase from rat liver and E. coli were tested for their ability to repair O4-methylthymine in a methylated poly(dT) X poly(dA) substrate. The bacterial preparation readily carried out this reaction, but no loss of O4-methylthymine was obtained with the rat liver protein. These results indicate a significant difference in specificity between the mammalian and bacterial proteins which could have important consequences for carcinogenesis and mutagenesis by alkylating agents in mammalian cells.
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