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  • Title: Investigations into the direct effects of insulin on hepatic ketogenesis, lipoprotein secretion and pyruvate dehydrogenase activity.
    Author: Laker ME, Mayes PA.
    Journal: Biochim Biophys Acta; 1984 Sep 12; 795(2):427-30. PubMed ID: 6383481.
    Abstract:
    In the rat liver perfused with whole rat blood containing either decreased or increased concentrations of non-esterified fatty acids, insulin decreased production of acetoacetate and 3-hydroxybutyrate and stimulated secretion of very-low-density-lipoprotein triacylglycerol. In these same livers, pyruvate dehydrogenase activity was not altered by insulin addition, although it was diminished by non-esterified fatty acids.
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