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  • Title: Induction of puberty in a patient with hypogonadotropic hypogonadism by pulsatile, subcutaneous infusions of LH-RH.
    Author: Vierhapper H.
    Journal: Exp Clin Endocrinol; 1984 Jul; 84(1):126-8. PubMed ID: 6383847.
    Abstract:
    Following treatment with nocturnal, pulsatile, s.c. infusions of LH-RH (50 micrograms/night) for nine nights a twenty-year-old patient with hypogonadotropic hypogonadism presented a markedly enhanced, biphasic secretion of LH during an LH-RH infusion test (200 micrograms LH-RH i.v., t = 4 hours) indicating a hypothalamic defect and a deficiency in endogenous LH-RH production. Puberty was subsequently initiated in this patient within eight weeks of therapy with s.c. pulsatile LH-RH. These results confirm that intermittent application of LH-RH induces pituitary sensitization resulting in an enhanced response to exogenous LH-RH. This will help to select patients for prolonged therapy with intermittent s.c. LH-RH for the initiation of puberty.
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