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  • Title: Developmental changes in rat liver alcohol dehydrogenase.
    Author: Lad PJ, Shoemaker WJ, Leffert HL.
    Journal: Dev Biol; 1984 Oct; 105(2):526-9. PubMed ID: 6383901.
    Abstract:
    Hepatic alcohol dehydrogenase activity and mass content change coordinately during development in male rats. Enzyme activity and mass content increase continuously after birth to 100 and 80% of maximal values within 6 weeks (2.6 +/- 0.4 mumole/min/g liver and 92 +/- 20 micrograms/g liver), respectively. When expressed per milligram of soluble proteins, both parameters peak at 3 weeks (0.052 +/- 0.002 mumole/min/mg protein and 2.0 +/- 0.4 micrograms/mg protein) and then decrease gradually to plateau levels. These decreases probably arise from a "surge" in soluble liver protein levels that occurs after weaning. Similar developmental patterns also occur in female rats. These findings are the first quantitative measurements of this enzyme in developing animals.
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