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  • Title: Chronic delta hepatitis: a difficult problem for the hepatologist.
    Author: Picciotto A, Celle G.
    Journal: Hepatogastroenterology; 1984 Aug; 31(4):162-3. PubMed ID: 6383995.
    Abstract:
    Delta antigen was detected by means of direct immunofluorescence in the liver of 20 out of 118 chronic carriers of hepatitis B surface antigen (HBsAg). Delta antigen was frequently found in young chronic HBsAg carriers with chronic active hepatitis. Positivity for anti-HBe occurred in almost all cases. A peculiar aspect of delta infection was a predominance in patients from Southern, rather than from Northern or Central Italy. Another interesting finding is the higher mean values of GOT and GPT in delta-positive patients compared with those in delta-negative patients. The follow-up of some patients confirmed that chronic delta hepatitis is a particularly progressive disease.
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