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  • Title: Disappearance of enkephalins in the isolated perfused rat lung.
    Author: Manwaring D, Mullane K.
    Journal: Life Sci; 1984 Oct 22; 35(17):1787-94. PubMed ID: 6384711.
    Abstract:
    Enkephalin disappearance during a single passage through the isolated, Krebs'-perfused rat lung was examined by superfusion bioassay. The rat colon was used to quantitate enkephalin disappearance since it proved to be sensitive to physiologic concentrations (10(-11) M) of met5-enkephalin or an analog D-ala2-D-leu5-enkephalin. The rat stomach strip was used to assess the release of prostaglandins from the pulmonary vasculature. The rat lung rapidly degraded the enkephalins but released no prostaglandins in the dose-range of 0.1 - 50 ng. Captopril at doses which blocked conversion of angiotensin I to II inhibited the degradation of enkephalins across the lung.
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