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  • Title: Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line.
    Author: Sidell N, Lucas CA, Kreutzberg GW.
    Journal: Exp Cell Res; 1984 Nov; 155(1):305-9. PubMed ID: 6386496.
    Abstract:
    The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. The specific activity of AChE was significantly increased 3 days after exposure of LA-N-5 to RA and reached its maximum values after 9 or more days of culturing. Dose-response experiments demonstrated that large increases of AChE occurred at RA concentrations between 10(-7) and 10(-6) M with maximum AChE values detected at 10(-6)-10(-5) M. Increased AChE activity paralleled neurite outgrowth in LA-N-5 cultures. These findings demonstrate that RA can regulate specific AChE activity in human neuroblastoma cells in a manner consistent with neuronal maturation.
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