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  • Title: The desensitization effect of progesterone on female rat sexual behavior is not due to interference with estrogen priming.
    Author: Gilchrist SM, Blaustein JD.
    Journal: Physiol Behav; 1984 May; 32(5):879-82. PubMed ID: 6387731.
    Abstract:
    In order to determine if progesterone interferes with estradiol's priming action on progesterone-facilitated sexual behavior, we tested the responsiveness of progesterone-desensitized female rats to the serotonin receptor antagonist, methysergide, and the neuropeptide, luteinizing hormone-releasing hormone. Threshold doses of both compounds were established. Progesterone treatment, which caused a decrease in the lordosis rating in response to a moderate dose of progesterone did not inhibit responsiveness to threshold doses of methysergide or luteinizing hormone-releasing hormone. The results of this study support the notion that progesterone does not interfere with estradiol's priming action on progesterone-facilitated sexual receptivity. Furthermore, they suggest that progesterone's desensitization effect is specific to progesterone-facilitated lordosis.
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