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  • Title: [Combined (surgical and drug) therapy of parkinsonism].
    Author: Kandel' EI, Iadgarov IS.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1984; 84(8):1157-61. PubMed ID: 6388198.
    Abstract:
    Stereotaxic surgical operations on the basal cerebral ganglia are effective in the tremor and tremor-rigid forms of parkinsonism. Surgery is followed by an increased excretion of dopamine with a good clinical effect in most cases. Madopar (L-DOPA with an inhibitor DOPA-decarboxylase) is most effective in the akinetic and rigid-akinetic forms of the disease. Prolonged treatment with this drug leads to a sharp increase in DOPA and less significant in dopamine secretion. The effect of a single low dose of madopar on DOPA and dopamine excretion can be detected for six hours. When stereotaxic operation is indicated, the combined (surgery plus drug therapy) treatment of parkinsonism is most optimal. Following effective stereotaxic surgery, drug therapy should be continued with reduced dosage of the drugs.
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