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  • Title: [Action of diucifon-treated syngeneic splenic cells of mice on the magnitude of the immune response].
    Author: Leskov VP, Pisarev VM, Arshinova SS.
    Journal: Biull Eksp Biol Med; 1984 Oct; 98(10):474-6. PubMed ID: 6388660.
    Abstract:
    It was demonstrated previously that treatment of lymphocytes with the immunostimulant diucifon leads to the secretion of a substance having the biological activity of T cell growth factor. The present work demonstrates that injection into mice on the day of immunization of spleen syngeneic cells treated with diucifon increases the immune response 3-5-fold as compared to the action of untreated cells. Injection of spleen cells incubated without diucifon on day 3 after immunization significantly increases the immune response as compared with control. The cells treated with diucifon and injected at the same time reduce the immune response as compared with the action of spleen cells incubated without diucifon. The data obtained can be used during immunostimulant therapy.
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