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  • Title: Hormone and blood pressure relationships in primary aldosteronism.
    Author: Nicholls MG, Espiner EA, Ikram H, Maslowski AH, Hamilton EJ, Bones PJ.
    Journal: Clin Exp Hypertens A; 1984; 6(8):1441-58. PubMed ID: 6388912.
    Abstract:
    We used continuous intra-arterial pressure monitoring and hourly venous hormone sampling over 24 hours in 5 patients with primary aldosteronism to study blood pressure and hormone regulation. Three patients were restudied under identical conditions of controlled diet electrolyte intake and body posture 3-7 months after removal of the aldosterone-secreting adrenal tumor. Prior to surgery there was no positive relationship of arterial pressure to renin or to aldosterone. Norepinephrine fluctuations showed positive correlations with arterial pressure but these 2 indices were more closely related after surgery. Plasma aldosterone levels paralleled those of cortisol both before and after cure of primary aldosteronism. Aldosterone/cortisol regression lines were steeper before surgery, and norepinephrine/renin regression lines were steepened in the post-operation studies. Our findings indicate that in established primary aldosteronism, fluctuations in arterial pressure are regulated in part by the sympathetic nervous system: the pattern of aldosterone secretion is controlled mainly by ACTH: aldosterone responsiveness to endogenous ACTH is enhanced: and sympathetic modulation of renin release in inhibited.
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