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  • Title: Decrease in 5'-nucleotidase activity in malignant transformed and normal stimulated cells.
    Author: Raz A, Collard JG, Inbar M.
    Journal: Cancer Res; 1978 May; 38(5):1258-62. PubMed ID: 639059.
    Abstract:
    Analysis of six different cell types of normal and transformed fibroblasts grown in vitro and of four different cell types of normal and leukemic lymphocytes grown in vivo have shown a marked decrease of 3- to 30-fold in the specific activity of 5'-nucleotidase in the malignant cells as compared to their normal parental cells. The results have also indicated that a serum stimulation of untransformed or normal fibroblasts and a stimulation of normal lymphocytes by concanavalin A resulted in a significant decrease in the specific activity of 5'-nucleotidase of the stimulated cultures as compared to the resting cells. In both the malignant cells and the stimulated normal cells, the decrease in 5'-nucleotidase activity was not accompanied by a similar decrease in the specific activity of acid phosphatase, indicating a specific enzyme alteration in the surface membranes of the transformed and the normal stimulated cells.
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