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  • Title: [Use of heparin in combination with dihydroergotamine for the postoperative prevention of thrombosis in hip joint surgery].
    Author: Liedloff H, Brauckhoff KF, Heerdegen R, Barthel W.
    Journal: Z Gesamte Inn Med; 1984 Sep 01; 39(17):428-31. PubMed ID: 6390998.
    Abstract:
    The risk of thromboembolism is particularly high in patients involved in hip replacement arthroplasty. Therefore, besides physico-mechanical measures, early mobilisation, compression bandages and physiotherapy they need an additional pharmacological prophylaxis of thromboembolism. In the present study the prophylactic efficacy of low-dose heparin in combination with dihydroergotamine was investigated in 200 patients undergoing hip replacement. While in comparison to the only administration of low-dose heparin the frequency of thromboses of the deep veins of the leg did not decrease significantly, the decrease of the frequency of pulmonary embolism under the combination obtained statistical significance. The results are compared with those of studies published in international literature. Consequently, the application of low-dose heparin in combination with dihydroergotamine represents a simple, highly effective prophylaxis against thromboembolism, but is not free from side-effects.
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