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  • Title: Combined disease-modifying chemotherapy for intractable rheumatoid arthritis.
    Author: Bitter T.
    Journal: Clin Rheum Dis; 1984 Aug; 10(2):417-28. PubMed ID: 6391796.
    Abstract:
    When one endeavours to obtain lasting remissions in long-standing or erosive and/or highly seropositive, i.e. unrelenting, RA, combined 'aggressive' two-drug therapy appears to be reasonably well tolerated. Surprisingly, gold and D-penicillamine are not antagonistic but appear to potentiate each other to give the best results. In analogy with lymphoma and with the open trial by McCarty--and in the absence of new major 'disease-modifying' drugs--the door should be kept wide open towards controlled trials of combined three-drug chemotherapy.
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