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  • Title: Optimal iodine concentration in digital subtraction arteriography.
    Author: Norman D, Brant-Zawadzki M, Gould RG, Newton TH.
    Journal: Invest Radiol; 1984; 19(6 Suppl):S368-70. PubMed ID: 6392167.
    Abstract:
    The effects of two different concentrations of the contrast agent Hexabrix were evaluated in a total of 26 patients undergoing cerebral angiography and randomly assigned to two groups. Injection volume, rate, and iodine concentration were constant. Carotid digital exams using 8% and 12% Hexabrix in the same patient showed the higher concentration was preferred for vessels of all sizes. In comparing 12% and 16% concentrations of Hexabrix, there was again a preference for the higher concentration, although results were not statistically significant. Both 12% and 16% Hexabrix in carotid studies resulted in excellent quality exams. Vessel see-through ability was somewhat better with 12% Hexabrix. Subjective symptoms of all patients during the injection were minimal or absent. Hexabrix is theoretically more attractive than conventional agents in that optimal concentration for digital imaging is in a range which is iso-osmotic with serum.
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