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  • Title: Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin.
    Author: Müller H, Bräuer H, Resch B.
    Journal: Clin Chem; 1978 Apr; 24(4):706-9. PubMed ID: 639280.
    Abstract:
    We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and solid-phase) kit procedures. Both tests showed similar average percentages of cross reactivity with digitoxin (7.2 and 8.9% for intravenous, and 11.9 and 10.9% for oral administration), but no cross reactivity with spironolactone or its metabolites after equal intravenous or oral doses.
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