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  • Title: 13C NMR studies of glycolysis in intra- and extra-erythrocytic Babesia microti.
    Author: Mackenzie NE, Johnson J, Burton G, Wagner GG, Scott AI.
    Journal: Mol Biochem Parasitol; 1984 Sep; 13(1):13-20. PubMed ID: 6392883.
    Abstract:
    Metabolism in the erythrocytes of normal mice and mice infected with Babesia microti has been monitored non-invasively by high resolution 13C NMR spectroscopy. The conversion of [U-13C]glucose to lactate in both normal and infected cells together with the effect of the trypanocidal drug, 4,4'-diamidinodiazoaminobenzene diaceturate, on glycolytic rates were monitored. These studies show that erythrocytes utilize [U-13C]glucose at a rate of 3 X 10(-12) mumol cell-1 min-1 at 35 degrees C while parasitized cells consume 2.9 X 10(-11) mumol cell-1 min-1 and produce lactate as the sole end-product. This rate decreases to 9 X 10(-12) mumol cell-1 min-1 on the addition of 0.75 mM drug.
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