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  • Title: Inhibition of platelet aggregation by a new agent, 5-(Z,E)-13,14-didehydro-20-methyl-carbo PGI2 (FCE 22509).
    Author: Bergamaschi M, Pierucci L, Ferti C, Corsi G, Branzoli U, Mandelli V.
    Journal: Prostaglandins Leukot Med; 1984 Oct; 16(1):19-27. PubMed ID: 6393142.
    Abstract:
    FCE (+)22509, a chemically stable carboprostacyclin analogue, inhibited in vitro ADP-induced platelet aggregation in rat platelet-rich plasma (PRP) (IC50 = 7.7 ng/ml). Subcutaneous administration of the drug, inhibited both ADP-induced platelet aggregation in rat PRP (ED50 = 0.26 mg/kg) and mortality of mice induced by collagen plus adrenaline (ED50 = 0.35 mg/kg). The compound had no such preventive effects when given orally.
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