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  • Title: The bone biopsy protocol for evaluating osteoporosis and osteomalacia.
    Author: Vigorita VJ.
    Journal: Am J Surg Pathol; 1984 Dec; 8(12):925-30. PubMed ID: 6393777.
    Abstract:
    Although this paper has dealt with well-established diagnostic procedures, I have attempted to present a practical summary based on experience with over 400 cases. A complete and modern approach to the evaluation of the bone biopsy for metabolic bone disease may be summarized as follows: Preoperative double labeling with tetracycline (two 3-day courses of tetracycline separated by 12 days); Full-thickness iliac bone biopsy yielding a 5- to 6-mm diameter specimen; Undecalcified sectioning (5-10 mu) processed in glycol or methyl methacrylate; Histomorphometric analysis with light microscope and planimeter; Tetracycline analysis with fluorescent microscope.
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