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  • Title: Circadian rhythms in the aged: a review.
    Author: Casale G, de Nicola P.
    Journal: Arch Gerontol Geriatr; 1984 Oct; 3(3):267-84. PubMed ID: 6395821.
    Abstract:
    After a review of the fundamental concepts on chronobiology, the importance of circadian rhythms in the aged was examined on the basis of the data obtained in animals and humans, including personal observations on over 40 blood constituents. During ageing there are significant modifications of circadian rhythms, with frequent diminution of amplitude and a shift of acrophase. The biological, clinical and therapeutic implications of these findings are discussed.
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