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  • Title: [Phase II study of the treatment of CML blast crisis with vindesine and prednisone].
    Author: Jehn U, Mezger J.
    Journal: Onkologie; 1984 Dec; 7(6):342-5. PubMed ID: 6396561.
    Abstract:
    16 patients with CML-BC were treated with vindesine/prednisone. Complete remissions were achieved in 3 cases which lasted 1 month (myeloid), 3 months (mixed) and 5 months (lymphoid). Minor responses, including less than 50% reduction of absolute blast counts and marked regression of organomegaly with a median duration of 3 weeks, occurred in 11 patients. Two patients did not respond to VDS. Leukopenia and thrombocytopenia were severe and prolonged, independent of their phenotype.
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