These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Anticoagulating properties of fungal proteases tricholysine (triase) and longolytin].
    Author: Serebriakova TN, Andreenko GV, Maksimova RA, Tsymanovich ST, Murashova NL.
    Journal: Vopr Med Khim; 1984; 30(5):37-40. PubMed ID: 6396943.
    Abstract:
    Tricholysine (triase) and longolytin, isolated from cultural fluid of two similar lower fungi Trichothecium roseum and Arthrobotrys longa, exhibited anticoagulant and fibrinolytic properties after addition to blood plasma of experimental animals. Intravenous administration of the enzymes into animals caused the following effects: an increase in fibrinolytic activity, a slight decrease of fibrinogen concentration, an inadequate elongation of recalcification time and of thrombin time. Analysis of thromboelastograms demonstrated the anticoagulant effect: index of coagulation and maximal amplitude were decreased, time of coagulation was elongated. Preparation of tricholysine exhibited low toxicity; only doses, which exceeded 80-fold the thrombolytic dose, caused death in 34% of mice after intravenous administration.
    [Abstract] [Full Text] [Related] [New Search]