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  • Title: [A radioimmunoassay for plasma 11-desoxycortisol and its use in the rapid metopirone test].
    Author: Hubl W, Büchner M, Haussig K, Rohde W, Stahl F.
    Journal: Endokrinologie; 1978 Feb; 71(1):60-4. PubMed ID: 639765.
    Abstract:
    A radioimmunoassay for the measurement of 11-deoxycortisol in plasma is described. Antiserum against 11-deoxycortisol was produced by immunizing rabbits with the 21-hemisuccinate of 11-deoxycortisol coupled to bovine serum albumin. The method does not require chromatography but instead makes use of a simple extraction procedure which, in combination with the antibody characteristics, is relatively specific for the 11-deoxycortisol determination. The smallest amount measurable is 5 pg. The intra-assay coefficient of variation was 6.3% before metopirone and 7.2% after metopirone. The inter-assay coefficient of variation was 12.5% before metopirone and 10.3% after metopirone. Pituitary-adrenal reserve was evaluated in control and hypopituitary subjects by a simple midnight metopirone test.
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