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  • Title: Mutagenic effects of psoralens in yeast and V79 Chinese hamster cells.
    Author: Averbeck D, Papadopoulo D, Quinto I.
    Journal: Natl Cancer Inst Monogr; 1984 Dec; 66():127-36. PubMed ID: 6397690.
    Abstract:
    The mutagenic effects of monofunctional and bifunctional furocoumarins (psoralens) plus 365 nm radiation were analyzed in the yeast Saccharomyces cerevisiae. Per unit dose of 365-nm radiation, bifunctional compounds were more effective than were the monofunctional for the induction of reverse and forward mutations. The same was observed for the induction of 6-thioguanine-resistant mutants in V79 Chinese hamster cells when we compared the activity of 8-methoxypsoralen and 3-carbethoxypsoralen. An analysis of the kinetics of mutation induction indicated that DNA interstrand cross-links induced by bifunctional psoralens are more prone to error than are monoadducts induced by monofunctional psoralens. In yeast, 8-methoxypsoralen and 4,5'-dimethylangelicin were shown to photoinduce mitotic and nondisjunction. The implications of these findings for the use of psoralens in photochemotherapy and cosmetics are discussed.
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