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  • Title: Cross-reactive transplantation antigens between UV-irradiated skin and UV-induced tumors.
    Author: Spellman CW, Daynes RA.
    Journal: Photodermatol; 1984 Aug; 1(4):164-9. PubMed ID: 6397735.
    Abstract:
    The fate of ultraviolet (UV) light-induced tumors transplanted into syngeneic hosts bearing skin grafts from UV-irradiated donors was studied. Our results suggest that UV-irradiated skin and UV-induced tumors express common antigens. Further, these results may bear on the question of how subcarcinogenic doses of UV radiation can effect the generation of tumor antigen-specific T suppressor cells prior to the existence of UV-induced tumors. Specifically, normal C3Hf/HeJ mice were grafted with UV-irradiated, or normal skin and subsequently implanted with either regressor, progressor, or conversion type UV-induced tumors. Animals bearing UV skin grafts were: a) effectively immunized against conversion type tumors, b) exhibited no differences against regressor type tumors, and c) allowed progressor type tumors to grow at an accelerated rate.
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