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  • Title: Absence of effect of the peptide PHI-27 on LH release in vitro.
    Author: Miyake A, Tasaka K, Ohtsuka S, Yanaihara N, Nokihara K, Aono T.
    Journal: Endocrinol Jpn; 1984 Dec; 31(6):821-4. PubMed ID: 6398220.
    Abstract:
    The effects of PHI-27, a peptide of the glucagon-secretion family, on luteinizing hormone (LH) release and on LH-releasing hormone (LH-RH)- or estradiol-induced LH release were examined in a sequential double chamber perifusion system by perifusing the pituitary alone or in sequence with the mediobasal hypothalamus (MBH) from normal female rats in diestrus. PHI at 10(-7) M had no significant effect on LH release from the pituitary in series with the MBH. Moreover, on perifusion of the pituitary alone with medium containing 10(-7) M PHI, LH release induced by 20 ng/ml LH-RH from the pituitary was not significantly different from that without PHI. Furthermore, PHI had no effect on estradiol-induced LH release from the pituitary in sequence with the MBH. These data indicate that PHI has no effect on LH release in vitro.
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