These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synergistic actions of prostacyclin and an isoquinoline derivative (CH-102) on ADP-induced aggregation of dog platelets in vitro.
    Author: Pataricza J, Bor P, Szekeres L.
    Journal: Biomed Biochim Acta; 1984; 43(12):1365-9. PubMed ID: 6398698.
    Abstract:
    The effect of an isoquinoline derivative, CH-102, and of prostacyclin-Na alone and their combinations on ADP-induced aggregation of dog platelets in vitro was studied. CH-102 and prostacyclin inhibited platelet aggregation in a dose-related manner with IC50 values of 3.2 X 10(-5) mol/l and of 4.8 X 10(-9) mol/l, respectively. CH-102 enhanced the platelet aggregation inhibitory effect of prostacyclin in a concentration range of 10(-6) to 2.3 X 10(-5) mol/l. The mode of interaction of the two agents characterized by the isobolic curve is a potentiated synergism.
    [Abstract] [Full Text] [Related] [New Search]