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  • Title: Mefloquine-pyrimethamine-sulfadoxine combination delays emergence of mefloquine resistant Plasmodium falciparum in continuous culture.
    Author: Tan-Ariya P, Brockelman CR, Menabandhu C.
    Journal: Southeast Asian J Trop Med Public Health; 1984 Dec; 15(4):531-5. PubMed ID: 6398918.
    Abstract:
    The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.
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